(2018) Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. Pharmacology & Therapeutics. pp. 13-41. ISSN 0163-7258
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Abstract
Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of brain tumors remains a challenge. This is particularly true for the most frequent and fatal adult brain tumor, glioblastoma (GB). Upon diagnosis, the average survival time of GB patients remains only approximately 15 months. The alkylating drug temozolomide (TMZ) is routinely used in brain tumor patients and induces apoptosis, autophagy and unfolded protein response (UPR). Here, we review these cellular mechanisms and their contributions to TMZ chemoresistance in brain tumors, with a particular emphasis on TMZ chemoresistance in glioma stem cells and GB.
| Item Type: | Article |
|---|---|
| Keywords: | cell death apoptosis autophagy unfolded protein response brain tumor glioblastoma glioblastoma stem cells DNA repair bcl-2 family protein cancer therapy temozolomide alkylating drugs stem-like cells endoplasmic-reticulum-stress newly-diagnosed glioblastoma malignant glioma-cells base excision-repair bevacizumab plus irinotecan tumor-initiating cells central-nervous-system randomized phase-iii epithelial-mesenchymal transition |
| Divisions: | |
| Page Range: | pp. 13-41 |
| Journal or Publication Title: | Pharmacology & Therapeutics |
| Volume: | 184 |
| Identification Number: | 10.1016/j.pharmthera.2017.10.017 |
| ISSN: | 0163-7258 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.zbmu.ac.ir/id/eprint/2257 |
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