(2018) Biosynthesis of gold nanoparticles using Prosopis farcta extract and its in vitro toxicity on colon cancer cells. Research on Chemical Intermediates. pp. 3169-3177. ISSN 0922-6168
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Abstract
Gold nanoparticles (Au-NPs) were prepared by "green" synthesis through the aqueous extract of Prosopis farcta. The P. farcta is a special herbal, which it can be a suitable candidate in the reduction process of Au3+ to Au-0. The structure and morphology of the synthesized Au-NPs were characterized by UV-visible spectrophotometry, powder X-ray diffraction analysis and high-magnification transmission electron microscopy techniques. The Au-NPs were spherically uniform in shape with particle size of about 25 nm. The cytotoxicity effect of Au-NPs was studied on a colon (HT-29) cancerous cell line via the MTT assay, and the IC50 of Au-NPs was calculated to be 419.7 A mu g/mL. The results indicated that the apoptotic effects were increased on cells when the Au-NPs concentration reached 200 A mu g/mL. The Au-NPs were synthesized easily and with a very low cost and time by P. farcta extract for the first time.
Item Type: | Article |
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Keywords: | gold nanoparticles prosopis farcta cytotoxicity apoptotic tunel assay green synthesis leaf extract mediated synthesis catalytic-activity silver apoptosis delivery assay l. |
Divisions: | |
Page Range: | pp. 3169-3177 |
Journal or Publication Title: | Research on Chemical Intermediates |
Volume: | 44 |
Number: | 5 |
Identification Number: | 10.1007/s11164-018-3299-y |
ISSN: | 0922-6168 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.zbmu.ac.ir/id/eprint/2256 |
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